An artificial sweetner and sugar substitute, known as sucralose, the majority of ingestion is not broken down by the body, so it is noncaloric. It is 320 times to 1000 times sweeter than sucrose, and many times sweeter than aspartame. It is used in many food and beverage products, mostly because it is a no-calorie sweetner. However, studies suggest dangers of using the product as reflected by Dr. Mercola, Mercola.com:
“Sucralose (sold under the brand name Splenda) was approved by the U.S. Food and Drug Administration (FDA) in 1998 as a tabletop sweetener and for use in products such as baked goods, nonalcoholic beverages, chewing gum, frozen dairy desserts, fruit juices and gelatins.
Image courtesy of: mrkittums
It’s also permitted as a general-purpose sweetener for processed foods. (In the European Union, sucralose is known under the additive code E955.) The approval was given after the FDA supposedly reviewed more than 110 animal and human safety studies, but of these 110 studies, only two were done on humans, and the longest one lasted just four days.
I knew the approval of sucralose was a nearly identical mistake that the FDA made with aspartame, which is why I wrote my book, “Sweet Deception,” in 2006, despite the fact Johnson & Johnson threatened to sue me if I published it. It is certainly vindicating to see the studies confirm what I wrote about in my book over 12 years ago. And the video I made above was shot over seven years ago.
Artificial sweeteners like aspartame and sucralose may have zero calories, but your body isn’t fooled. When hit with a “sweet” taste, your body expects calories to follow, and when this doesn’t happen, it causes biochemical distortions that can result in weight gain, metabolic dysfunction and other health problems.
Sucralose Decimates Your Gut Microbiome
Different artificial sweeteners have been found to wreak havoc in a number of different ways. Aspartame, for example, has a long list of studies detailing harmful effects ranging from brain damage to preterm delivery. Sucralose, meanwhile, has been found to be particularly damaging to your gut. Research1 published in 2008 found sucralose:
- Reduces gut bacteria by 50 percent, preferentially targeting bacteria known to have important human health benefits (consuming as few as seven little Splenda packages is enough to have a detrimental effect on your microbiome)
- Increases the pH level in your intestines
- Is absorbed into and accumulates in fat tissue
“The report makes it clear that the artificial sweetener Splenda and its key component sucralose pose a threat to the people who consume the product. Hundreds of consumers have complained to us about side effects from using Splenda and this study … confirms that the chemicals in the little yellow package should carry a big red warning label.”
New Study Finds Sucralose Is Metabolized and Stored in Your Body
Needless to say, the industry has vehemently defended sucralose (and all other chemical sweeteners), stating that it rapidly passes unmetabolized through your body and therefore has no biological effects. Alas, recent research has punched yet another giant hole in the argument that sucralose is a biologically inert chemical, showing it is in fact metabolized and that it accumulates in fat cells.
Image courtesy of: fishhawk
Ten rats were given an average dose of 80.4 milligrams (mg) of sucralose per kilo per day (k/day) for 40 days. According to the researchers, this dosage is “within the range utilized in historical toxicology studies submitted for regulatory approval in North America, Europe and Asia.”
Urine and feces were collected daily from each rat, and were analyzed using ultrahigh performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS), which “revealed two new biotransformation products that have not previously been reported.”
Research Calls for New Safety Review of Sucralose
The two metabolites are acetylated forms of sucralose that are lipophilic, meaning they dissolve in and combine with fats. Sucralose itself is far less lipophilic, which has been part of the safety argument. According to the authors:
“These metabolites were present in urine and feces throughout the sucralose dosing period and still detected at low levels in the urine 11 days after discontinuation of sucralose administration and six days after sucralose was no longer detected in the urine or feces.
The finding of acetylated sucralose metabolites in urine and feces do not support early metabolism studies, on which regulatory approval was based, that claimed ingested sucralose is excreted unchanged (i.e., not metabolized).
The historical metabolic studies apparently failed to detect these metabolites in part because investigators used a methanol fraction from feces for analysis along with thin layer chromatography and a low-resolution linear radioactivity analyzer.
Further, sucralose was found in adipose tissue in rats two weeks after cessation of the 40-day feeding period even though this compound had disappeared from the urine and feces.”
So, not only is sucralose metabolized, these metabolites accumulate in your fat tissues, where they remain for “an extended period of time” after you stop consuming sucralose. In all, these findings led the authors to conclude:
“These new findings of metabolism of sucralose in the gastrointestinal tract and its accumulation in adipose tissue were not part of the original regulatory decision process for this agent and indicate that it now may be time to revisit the safety and regulatory status of this organochlorine artificial sweetener.”
Sucralose Is Not an Inert Compound
Previous research has also noted that sucralose is not a biologically inert compound, as claimed. In the 2013 paper,6 “Sucralose, a Synthetic Organochloride Sweetener: Overview of Biological Issues,” the authors state, in part:
“Sucralose and one of its hydrolysis products were found to be mutagenic at elevated concentrations in several testing methods … Both human and rodent studies demonstrated that sucralose may alter glucose, insulin and glucagon-like peptide 1 levels. Taken together, these findings indicate that sucralose is not a biologically inert compound.”
Importantly, the study also notes that “Cooking with sucralose at high temperatures … generates chloropropanols, a potentially toxic class of compounds.” Yet, Splenda is frequently recommended for cooking and baking,7 and is often used in processed foods in which high heat was involved.
Chloropropanols, which are still poorly understood, are thought to have adverse effects on your kidneys and may have carcinogenic effects.8 However, it’s worth noting that chloropropanols are part of a class of toxins known as dioxins, and dioxins are known to cause cancer and endocrine disruption.”
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