The brain starts developing at conception and continues to grow until a person turns 21 years old – or so it was long believed. But brain growth doesn’t stop at that age. You can create new brain cells as you age, but only if you maintain an optimal environment for neurogenesis. Neurogenesis is the process by which neural stem cells (NSCs) differentiate into mature neurons. This plays a crucial role in neural plasticity and in the repair and replacement of cells that are damaged by the normal aging process and neurodegenerative diseases. Here Dr. Joseph Mercola, Mercola.com, reflects on ferulic acid for memory and skin improvement, since it has the ability to fight free radicals:
“What is the second most popular adaptogen next to panax ginseng? Many readers know it is rhodiola rosea, an herb that helps to ease fatigue, increase endurance and improve mood, in addition to other benefits. A perennial flowering plant, rhodiola rosea grows in the U.S., Europe, Asia and even the Arctic and is also known as golden root or roseroot.
The active compounds in rhodiola — rosavin, rosaridin, rosarin, rosin, salidroside and tyrosol — have been associated with many of its benefits. For example, rosavin is believed to exert antidepressant, anticancer, anti-inflammatory and antioxidative actions.1
Rosavin also created improvements in pulmonary fibrosis in mice, decreasing inflammatory cells infiltration and proinflammatory cytokines expression and downregulating oxidative chemicals.
Salidroside, another rhodiola ingredient, reduced hepatic steatosis in Type 2 diabetic mice, which holds implications for the treatment of high-fat, diet-induced nonalcoholic fatty liver disease.2 Now, another ingredient in rhodiola, an ester called ferulic acid, is being studied and showing new benefits for its positive actions.3
New Ferulic Acid Benefits Are Being Explored
Ferulic acid (FA), a phenolic phytochemical in rhodiola, is also found in rice, wheat, oats, pineapple, artichoke, peanut, nuts and even the seeds of coffee.4 While ferulic acid has been used in skin preparations, many other uses are being explored. It may, for example, have value in treating cancer, diabetes, pulmonary, heart and liver conditions, mental acuity and oxidative stress, according to research in Biotechnology Reports.5
“It has been proved that FA acts as a β-secretase modulator with therapeutic potential against Alzheimer’s disease, and found to improve the structure and function of the heart, blood vessels, liver, and kidneys in hypertensive rats …
Researchers have also proved that at lower concentration, FA reduced the cell death in hippocampal neuronal cells induced by peroxyl radical, while at higher concentration, it diminished the hydroxyl radicals induced by protein oxidation and peroxidation of lipid. FA helped in the reduction of lipid peroxidation in peripheral blood mononuclear cells.”
In an article in the journal Natural Product Research, ferulic acid was found to relieve oxidative stress in rat heart cells. The researchers also explored ferulic acid's ability to protect against oxygen-glucose deprivation.6
Ferulic Acid Shows Brain Benefits
Some of the most exciting brain and memory actions associated with ferulic acid obtained from rhodiola were published in Science Advances.7 Researchers found that ferulic acid ester dramatically improves recall in fruit flies, bees and mice.8 According to Harvard magazine:9
“[Researchers] made a sucrose solution with the shredded-root tea … The team engaged the bees in a classical conditioning paradigm in which they dribbled a tiny amount of sucrose solution onto a toothpick while blowing a particular odor at the animal.
As a result, the bees came to remember the sucrose reward in association with that particular odor, confirming memory acquisition. The next day, the bees still remembered the odor and expected the sucrose solution, confirming memory consolidation.”
Hanna Zwaka, who participated in the research, summarized the results:10
“Imagine you’re learning for a test — that would be the memory acquisition, and in this case, that’s when the bees paired the odor with that reward. The next day, you have to recall the memory, but this recall can also depend on sleep and concentration levels independent of the memory consolidation, which happens after you learn something …
We gave the bees Rhodiola before the learning phase [in which the bees learned to associate the sucrose solution with a particular odor], and we saw that the learning during the memory acquisition worked better than in a control group. When we gave them Rhodiola after learning, in the time when memory was consolidated, they performed better on the next day.”
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Read More … Article Source: https://articles.mercola.com/sites/articles/archive/2020/02/17/ferulic-acid-from-rhodiola-great-for-skin-and-brain.aspx
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