Herbs and spices are a must-have in your kitchen. These natural flavor-boosters can make any dish more delicious, and they also offer health benefits like boosting your immunity or lowering the risk of certain health conditions, as previously noted. Here Evangelyn Rodriguez, NaturalNews.com, reflects on anti-cancer compound in great burnet herb:

“The flowering plant scientifically known as Sanguisorba officinalis (great burnet) is a common Chinese herbal medicine used to stop bleeding and reduce inflammation. Research suggests that it has great therapeutic potential due to its broad range of biological properties, which include anti-inflammatory, antioxidant and anti-cancer properties.

In a recent study published in the journal Chinese Medicine, Chinese researchers explored the molecular mechanism behind great burnet’s anti-cancer activity against colorectal cancer cells. They found that one of its active components can stop the Wnt/B-catenin signaling pathway, which is involved in cell proliferation and self-renewal. When dysregulated, this pathway contributes to the development of diseases like colorectal cancer.

A compound in great burnet targets genes involved in cancer

To investigate the ability of great burnet to inhibit the growth of cancer cells, the researchers first extracted one of its main bioactive compounds, 1,4,6-Tri-O-galloyl-B-D-glucopyranose (TGG). TGG is classified as a tannin, an organic subtance with astringent properties often found in the galls and barks of various plants. They tested the anti-cancer activities of TGG by treating mouse embryonic fibroblasts (NIH3T3) and human colon adenocarcinoma cells (HT29) with it.

Using different assays and biochemical techniques, the researchers measured the expression levels of relevant proteins and detected their presence in the cytoplasm and nucleus of both cell lines. They also conducted transcriptomic profiling – a method used to understand the genetic regulation of a particular cell type – to understand the mechanism by which TGG exerts its effect on the Wnt/B-catenin signaling pathway.

Wnt/B-catenin signaling is a crucial component of cell development. It helps direct cell proliferation, cell component organization and cell differentiation. Because of its heavy involvement in critical cellular events, mutations in this pathway are often linked to birth defects and serious diseases like cancer.

Studies have shown that the excessive activation of the Wnt/B-catenin signaling pathway is involved in the development of colorectal cancer. In their study, the researchers found that TGG from great burnet can inhibit this signaling pathway by down-regulating the expression of B-catenin. B-catenin is a transcriptional activator that enables the expression of Wnt target genes, which are known to play various roles in the survival and proliferation of different types of cancer.”

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