Ginseng is a widely used Oriental herb that is known for its ability to improve physical, psychomotor, and cognitive performance, as well as the functions of the cardiovascular, immunological, endocrine, reproductive, and nervous systems. Moreover, this herb has been shown to have anti-inflammatory, antioxidant, and antitumor activity, as previously noted. Here Evangelyn Rodriguez, NaturalNews.com, reflects on therapeutic effects of ginseng on Alzheimer's disease:

“Panax ginseng, commonly known as Asian ginseng or Korean ginseng, is one of the most widely used and extensively studied species of ginseng. Sometimes referred to as the “true ginseng,” Asian ginseng has been a staple herb in Traditional Chinese Medicine (TCM) and is still used today to boost immunity, increase strength and blood volume, lower blood sugar, promote life and appetite and treat anemia and impotence.

In a recent study, American and Chinese researchers screened, identified and evaluated the bioactive compounds present in Asian ginseng. Specifically, they looked at the herb’s neuroprotective effects, which have been reported by numerous studies but remain poorly understood. The researchers reported their findings in an article published in The American Journal of Chinese Medicine.

Asian ginseng shows promise against Alzheimer’s disease

According to cell culture and animal studies, Asian ginseng exerts neuroprotective effects, but the specific bioactive compounds responsible for these effects and the mechanisms behind them still need to be investigated.

To screen, identify and evaluate the bioactive compounds present in this TCM herb, the researchers used affinity ultrafiltration (AUF), a combination of liquid chromatography and mass spectrometry (UPLC-QTOF-MS) and molecular docking for their experiment.

AUF is a method often used to fish out molecules of interest from complex matrices. UPLC-QTOF-MS, on the other hand, is used to characterize and identify phytochemicals present in plant extracts. Molecular docking is a method frequently used to predict the three-dimensional structure and binding-conformation of ligands to their receptors.

The researchers selected three macromolecules, namely, acetylcholinesterase (AChE), monoamine oxidase B (MAO-B) and the N-methyl-D-aspartate (NMDA) receptor, to be the target proteins for AUF-MS screening and found 16 potential neuroactive compounds present in Asian ginseng.”

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