A compound in the turmeric spice, curcumin is a bit of an overachiever in the health realm, grabbing headlines for its benefits in fighting everything from cancer to memory to arthritis. However, for many people, one of its most exciting benefits is its power to help fight depression, as previously noted. Here Evangelyn Rodriguez, NaturalNews.com, reflects on evidence supporting the use of curcumin as an alternative treatment for kidney fibrosis:
“Renal or kidney fibrosis is a progressive condition that results from the excessive accumulation of extracellular matrix proteins, which can cause structural damage to the kidneys. It signifies a failed wound-healing process and ultimately leads to end-stage kidney disease wherein the kidneys are no longer able to function as they should.
In a recent study, Chinese researchers explored the anti-fibrotic effects of curcumin, the active component of turmeric. Specifically, they looked at how curcumin affects epithelial-mesenchymal transition (EMT) and the activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. EMT refers to epithelial cells undergoing molecular changes and gaining new characteristics, such as an enhanced ability to produce ECM components. Meanwhile, the PI3K/Akt pathway is one of the major cell signaling pathways that regulate fibrosis.
The researchers reported their findings in an article published in the journal Biological and Pharmaceutical Bulletin.
Curcumin is an effective alternative treatment for renal fibrosis
According to several animal studies, curcumin can protect the kidneys by preventing the development of renal fibrosis. However, the mechanisms underlying this activity are still unknown.
To explore these mechanisms and the anti-fibrotic activities of curcumin, the researchers treated human kidney tubular epithelial cells (HKCs) with transforming growth factor-B1 (TGF-B1), curcumin and a combination of both. TGF-B1 is a protein that’s involved in many cellular functions, including cell growth, proliferation, differentiation and death, as well as the induction of EMT.”
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Read More … Article Source: https://www.naturalnews.com/2021-05-07-curcumin-alternative-treatment-for-kidney-fibrosis.html
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